Tuberculosis Case-finding by Tuberculin-testing of Infant-school Children

Tuberculosis case finding by tuberculin testing a complete population, with follow-up.

Transmission of Mycobacterium tuberculosis undetected by tuberculin skin testing.

RATIONALE The development of tuberculin skin test (TST) positivity following infection by Mycobacterium tuberculosis is not invariable and may depend on bacillary as well as host factors. OBJECTIVES First, to compare the diagnostic performance of the TST and a form of in vitro IFN-gamma release assay (IFNGRA) in the circumstances of a contact investigation prompted by an unusually severe inde...

Tuberculosis casefinding by tuberculin testing among various age children with a discussion of some theoretical problems.

We have previously reported the results of ten years of systematic tuberculin Qsting of kindergarten and first grade children in Kansas City, Missouri. This report adds seven yeas of testing in different age groups (8th and 9th; and 4th and 5th grades). As reported in the previous study, the prevalence rates and conversion rates to tuberculin are markedly different depending on the frequency at...

Tuberculin Skin Testing in Children

In 1996, the American Academy of Pediatrics (AAP) recommended targeted tuberculin skin testing (TST) of children while discouraging routine TST of children without risk factors for tuberculosis (TB). Recent studies have provided evidence in support of the targeted TST and recommendations that favor risk assessment over universal screening with TST. While evidence for targeted TB testing exists ...

Determining Mycobacterium tuberculosis Infection among BCG-Immunised Ugandan Children by T-SPOT.TB and Tuberculin Skin Testing

BACKGROUND Children with latent tuberculosis infection (LTBI) represent a huge reservoir for future disease. We wished to determine Mycobacterium tuberculosis (M.tb) infection prevalence among BCG-immunised five-year-old children in Entebbe, Uganda, but there are limited data on the performance of immunoassays for diagnosis of tuberculosis infection in children in endemic settings. We therefore...